Strategies to support Brain remodeling beyond acute stroke

Speaker: Dr. Carli Roulston

Laboratory Head of Pre-Clinical Stroke Research, Florey Institute of Neuroscience and Mental health

Date: Friday 4 pm on 16th November 2018 (no RSVP required)

Location: Mollison House, 384-388 Albert Street, East Melbourne, 3002

 

Abstract: 475,000 people in Australia alone are living with the permanent effects of stroke today. Stroke impedes mobility, limits daily life activities, and reduces the odds of returning to professional employment. Rehabilitation can improve outcome but is often directed towards compensation; and fatigue, depression and demoralisation impairs dedication to structured activities shown to support remodelling. Further to this the endogenous response to stroke also limits recovery, where inflammation and glial scarring impact even the non-damaged brain. This presentation will focus on our current understanding of how cells within the neurovascular unit are modified after stroke to contribute to functional decline, and how new treatments such as electrical brain stimulation, can restore these cells to improve recovery.

 

Dr Carli Roulston is Laboratory Head of Pre-Clinical Stroke Research at the Florey Institute of Neuroscience and Mental health where she leads independent and industry funded projects. Dr Roulston first commenced research in stroke during her PhD studies at Monash University in 2000 and was later recruited to the Howard Florey Institute with funding from Neuroscience Victoria to establish stroke models for assessing novel flavonoid compounds for neuroprotection. Work from these studies formed background IP to secure an international patent in 2006 and clinical trials with the novel small molecule NP202 (Armaron Biosciences Pty Ltd). In 2005 she relocated to the O’Brien Institute with independent funding to explore the role of free radicals in stroke injury and expanded her research to include mechanisms associated with brain regeneration. In 2009 she was appointed team leader of Neurotrauma research and commenced assessing new treatments to improve stroke recovery including stem cell transplants. In 2013 she relocated her team to the Department of Medicine to commence collaborations with Professor Mark Cook and A/Professor Chris Williams at the Bionics Institute, assessing brain stimulation strategies. In addition to contributions to basic science Dr Roulston is active within the broader community as a committee member for the Victorian Brain Bee, and a Board member for Stroke Association Victoria.

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