BSc (Hons), PhD 2002
Senior Research Fellow, Bionics Institute
P: +61 3 9667 7564
F: +61 3 9667 7542
Dr Wise graduated from Monash University (PhD) in 2002 where he studied neurophysiology of the sensorimotor system. He was a post doctoral research Fellow at the Bionic Ear Institute (2001-2003). He moved to Bristol UK where he took up post doctoral position (2003-2006) before returning to Melbourne in 2006 to continue research at the Bionics Institute.
Drug delivery: Dr Wise’s research examines strategies to deliver drugs to the inner ear in order to protect against progressive hearing loss and improve the performance of the cochlear implant by protecting auditory nerves and residual sensory cells. In particular he has been investigating the protective and regenerative effects of neurotrophins; a class of proteins that can protect cochlear cells from deafness-induced degeneration. His current research projects use a number of strategies to deliver drugs to the cochlea, along with a cochlear implant, that can be translated to the clinic.
Auditory function: Dr Wise is interested in how auditory neurons respond to electrical stimulation from a cochlear implant and the effects of neurotrophin delivery on nerve function. These experiments are an important next step before we can consider the use of neurotrophins as a therapy for human cochlear implant recipients.
Tinnitus: Dr Wise is interested in understanding the changes in the auditory brain that occur following deafness and cochlear implantation. In particular, he is interested in how cochlear implant use can silence tinnitus. By providing chronic electrical stimulation via a cochlear implant it is possible to suppress tinnitus and Dr Wise is interested in using this strategy to understand and treat tinnitus.
Publications (2014 - 2015)
Wise AK, Flynn BO, Atkinson PJ, Fallon JB, Nicholson M, et al. (2015) Regeneration of cochlear hair cells with Atoh1 gene therapy after noise-induced hearing loss. Journal of Regenerative Medicine (accepted).
Thompson AC, Fallon JB, Wise AK, Wade SA, Shepherd RK, et al. (2015) Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea. Hearing Research 324: 46-53.
George SS, Wise AK, Fallon JB, Shepherd RK (2015) Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats. Journal of Neural Engineering 12: 036003.
Xiao J, Cerminara NL, Kotsurovskyy Y, Aoki H, Burroughs A, et al. (2014) Systematic Regional Variations in Purkinje Cell Spiking Patterns. PLoS One 9: e105633.
Wang Y, Wise AK, Tan J, Maina JW, Shepherd RK, et al. (2014) Mesoporous silica supraparticles for sustained inner-ear drug delivery. Small 10: 4244-4248.
Wade SA, Fallon JB, Wise AK, Shepherd RK, James NL, et al. (2014) Measurement of forces at the tip of a cochlear implant during insertion. IEEE Trans Biomed Eng 61: 1177-1186.
Nayagam DA, Williams RA, Allen PJ, Shivdasani MN, Luu CD, et al. (2014) Chronic electrical stimulation with a suprachoroidal retinal prosthesis: a preclinical safety and efficacy study. PLoS One 9: e97182.
Maina JW, Cui J, Bjornmalm M, Wise AK, Shepherd RK, et al. (2014) Mold-templated inorganic-organic hybrid supraparticles for codelivery of drugs. Biomacromolecules 15: 4146-4151.
Irving S, Wise AK, Millard RE, Shepherd RK, Fallon JB (2014) A partial hearing animal model for chronic electro-acoustic stimulation. Journal of Neural Engineering 11: 046008.
Gillespie LN, Richardson RT, Nayagam BA, Wise AK (2014) Treating hearing disorders with cell and gene therapy. Journal of Neural Engineering 11: 065001.
George SS, Wise AK, Shivdasani MN, Shepherd RK, Fallon JB (2014) Evaluation of focused multipolar stimulation for cochlear implants in acutely deafened cats. Journal of Neural Engineering 11: 065003.
Fallon JB, Shepherd RK, Nayagam DAX, Wise AK, Heffer LF, et al. (2014) Effects of deafness and cochlear implant use on temporal response characteristics in cat primary auditory cortex. Hearing Research 315: 1-9.
Atkinson PJ, Wise AK, Flynn BO, Nayagam BA, Richardson RT (2014) Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs. PLoS One 9: e102077.
Shepherd RK, Wise AK (2014) Gene therapy boosts the bionic ear. Sci Transl Med 6: 233fs217.
Irving S, Gillespie L, Richardson R, Rowe D, Fallon JB, et al. (2014) Electroacoustic Stimulation: Now and into the Future. BioMed Research International 2014: 17.
Gillespie L, Richardson R, Wise AK, Nayagam BA (2014) Cell and Gene Therapies for the Treatment of Hearing Disorders. In: Templeton N, editor. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th ed: Taylor & Francis/CRC Press.