Tinnitus is the perception of sound in the absence of external input and while most of us have experienced tinnitus, for a significant number of people it can be a permanent and debilitating condition that cannot be treated. Tinnitus is most commonly triggered by trauma to the cochlea caused by loud noises. This project will investigate whether novel treatments such as drug therapy and cochlear implant use can reverse the maladaptive changes that occur following cochlear trauma. You will measure changes in tinnitus perception in behavioural experiments and use acute electrophysiological experiments to measure changes in neural firing properties, changes in functional connectivity, and changes in neuronal maps within and between these auditory centres.
Finally, gene expression in the auditory brain will be examined via molecular markers that are associated with changes in neural function.