A/Prof Andrew Wise
A/Prof Wise graduated from Monash University (PhD) in 2002 where he studied neurophysiology of the sensorimotor system. He was a post doctoral research Fellow at the Bionic Ear Institute (2001-2003). He moved to Bristol UK where he took up post doctoral position (2003-2006) before returning to Melbourne in 2006 to continue research at the Bionics Institute.
Drug delivery: A/Prof Wise’s research examines strategies to deliver drugs to the inner ear in order to protect against progressive hearing loss and improve the performance of the cochlear implant by protecting auditory nerves and residual sensory cells. In particular he has been investigating the protective and regenerative effects of neurotrophins; a class of proteins that can protect cochlear cells from deafness-induced degeneration. His current research projects use a number of strategies to deliver drugs to the cochlea, along with a cochlear implant, that can be translated to the clinic.
Auditory function: A/Prof Wise is interested in how auditory neurons respond to electrical stimulation from a cochlear implant and the effects of neurotrophin delivery on nerve function. These experiments are an important next step before we can consider the use of neurotrophins as a therapy for human cochlear implant recipients.
Tinnitus: A/Prof Wise is interested in understanding the changes in the auditory brain that occur following deafness and cochlear implantation. In particular, he is interested in how cochlear implant use can silence tinnitus. By providing chronic electrical stimulation via a cochlear implant it is possible to suppress tinnitus and A/Prof Wise is interested in using this strategy to understand and treat tinnitus.
- Drug delivery to treat hearing loss
- Developing a drug therapy for hearing loss
- Testing nano-engineered drug delivery systems to treat hearing loss
- Understanding changes in auditory processing from noise-induced hearing loss
- Optogenetics for precise neural stimulation
- Ma, Y., M. Björnmalm, A. K. Wise, C. Cortez-Jugo, E. Revalor, Y. Ju, O. M. Feeney, R. T. Richardson, E. Hanssen, R. K. Shepherd, C. J. H. Porter, and F. Caruso. 2018. Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery. ACS Applied Materials & Interfaces. 10(37): 31019-31031. doi: 1021/acsami.8b10415.
- Palmer, J. C., M. S. Lord, J. L. Pinyon, A. K. Wise, N. H. Lovell, P. M. Carter, Y. L. Enke, G. D. Housley, and R. A. Green. 2018. Comparing perilymph proteomes across species. Laryngoscope. 128(1): E47-e52. doi: 10.1002/lary.26885.
- Wise, A. K., R. Pujol, T. G. Landry, J. B. Fallon, and R. K. Shepherd. 2017. Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea. Journal of the Association for Research in Otolaryngology : JARO. 18(6): 751-69. doi: 10.1007/s10162-017-0631-y.
- Tang, T., J. Xiao, C. Y. Suh, A. Burroughs, N. L. Cerminara, L. Jia, S. P. Marshall, A. K. Wise, R. Apps, I. Sugihara, and E. J. Lang. 2017. Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations. The Journal of Physiology. 595(15): 5341-57. doi: 10.1113/JP274252.
- Shepherd, R. K., A. K. Wise, Y. L. Enke, P. M. Carter, and J. B. Fallon. 2017. Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study. Journal of Neural Engineering. 14(4): 046020. Full Text
- Richardson, R. T., A. C. Thompson, A. K. Wise, and K. Needham. 2017. Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss. Expert Opinion on Biological Therapy. 17(2): 213-23.
- Burroughs, A., A. K. Wise, J. Q. Xiao, C. Houghton, T. Y. Tang, C. Y. Suh, E. J. Lang, R. Apps, and N. L. Cerminara. 2017. The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes. Journal of Physiology-London. 595(1): 283-99. doi: 1113/JP272259. Full Text
- Wise, A. K., J. Tan, Y. Wang, F. Caruso, and R. K. Shepherd. 2016. Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea. PLoS ONE. 11(10): e0164867. doi: 1371/journal.pone.0164867. Full Text
- Fallon, J. B., S. Irving, S. S. Pannu, A. C. Tooker, A. K. Wise, R. K. Shepherd, and D. R. Irvine. 2016. Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data. Journal of Neuroscience Methods. 267: 14-20. Full Text
- Wise, A. K., B. O. Flynn, P. J. Atkinson, J. B. Fallon, M. Nicholson, and R. Richardson. 2015. Regeneration of cochlear hair cells with Atoh1 gene therapy after noise-induced hearing loss Journal of Regenerative Medicine. 4(1): doi:http://dx.doi.org/10.4172/2325-9620.1000121. Full Text
Shepherd RK, Wise AK (2014) Gene therapy boosts the bionic ear. Sci Transl Med 6: 233fs217.
Irving S, Gillespie L, Richardson R, Rowe D, Fallon JB, et al. (2014) Electroacoustic Stimulation: Now and into the Future. BioMed Research International 2014: 17.
Gillespie L, Richardson R, Wise AK, Nayagam BA (2014) Cell and Gene Therapies for the Treatment of Hearing Disorders. In: Templeton N, editor. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th ed: Taylor & Francis/CRC Press.