About us Our people Researchers and engineers A/Prof Andrew Wise A/Prof Wise graduated from Monash University (PhD) in 2002 where he studied neurophysiology of the sensorimotor system. He was a post-doctoral research Fellow at the Bionic Ear Institute (2001-2003). He moved to Bristol UK where he took up post-doctoral position (2003-2006) before returning to Melbourne in 2006 to continue research at the Bionics Institute. A/Prof Wise’s research focuses on understanding hearing impairment and developing therapeutic technology to treat it. In particular, he has been investigating the protective and regenerative effects of neurotrophins; a class of growth factors that can protect the inner ear sensory cells from degeneration. His current research projects use nanoengineering techniques to produce drug delivery particles that can deliver growth factors to the inner ear to treat hearing impairment. A/Prof Wise also has a research interest in cochlear implants and the development of new technologies to improve implant performance. The delivery of therapeutic drugs could one day be used to improve cochlear implant performance by protecting residual sensory cells. Furthermore, with the invention of optogenetic technology, it is now possible to modify auditory neurons so that they can be activated by light, in addition to electrical stimulation from a contemporary cochlear implant. This new way of activating the auditory neurons could lead to significant improvements in a future bionic ear device, for instance, by improving the understanding of speech in noisy environments. E: [email protected] Research projects Restoring hearing Optogenetics Understanding the hearing brain Safe and effective cochlear implants Student projects Testing nano-engineered drug delivery systems to treat hearing loss Developing a drug therapy for hearing loss Drug delivery to treat hearing loss Understanding changes in auditory processing from noise-induced hearing loss Optogenetics for precise neural stimulation Recent publications Richardson, R. T., M. R. Ibbotson, A. C. Thompson, A. K. Wise, and J. B. Fallon. 2020. Optical stimulation of neural tissue. Healthcare Technology Letters. 7(3): 58-65. doi: 1049/htl.2019.0114. Full Text Hart, W., R. Richardson, T. Kameneva, A. Thompson, A. K. Wise, J. B. Fallon, P. R. Stoddart, and K. Needham. 2020. Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency - An in vitro study. Journal of Neural Engineering. 17(1): 016069. doi: 1088/1741-2552/ab6a68. Ma, Y., C. Cortez-Jugo, J. Li, Z. Lin, R. T. Richardson, Y. Han, J. Zhou, M. Bjornmalm, O. M. Feeney, Q. Z. Zhong, C. J. H. Porter, A. K. Wise, and F. Caruso. 2019. Engineering Biocoatings To Prolong Drug Release from Supraparticles. Biomacromolecules. 20(9): 3425-3434. doi: 1021/acs.biomac.9b00710. Hart, W. L., T. Kameneva, A. K. Wise, and P. R. Stoddart. 2019. Biological Considerations of Optical Interfaces for Neuromodulation. Advanced Optical Materials: 1900385. doi: 1002/adom.201900385. Pinyon, J. L., G. von Jonquieres, E. N. Crawford, M. Duxbury, A. Al Abed, N. H. Lovell, M. Klugmann, A. K. Wise, J. B. Fallon, R. K. Shepherd, C. S. Birman, W. Lai, D. McAlpine, C. McMahon, P. M. Carter, Y. L. Enke, J. F. Patrick, A. G. M. Schilder, C. Marie, D. Scherman, and G. D. Housley. 2019. Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes. Hearing Research. 380: 137-149. doi: 1016/j.heares.2019.06.002. Ma, Y., A. K. Wise, R. K. Shepherd, and R. T. Richardson. 2019. New molecular therapies for the treatment of hearing loss. Pharmacology & therapeutics: pii: S0163-7528(0119)30077-30074. doi: 1016/j.pharmthera.2019.05.003. Full Text Richardson, R. T., Q. Y. Hu, F. Shi, T. Nguyen, J. B. Fallon, B. O. Flynn, and A. K. Wise. 2019. Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery. Journal of controlled release : official journal of the Controlled Release Society. 299: 53-63. doi: 1016/j.jconrel.2019.02.018. Shepherd, R. K., P. Carter, Y. L. Enke, A. K. Wise, and J. B. Fallon. 2018. Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo. Journal of Neural Engineering. 16(2): 026009. doi: 1088/1741-2552/aaf66b. Full Text Ma, Y., M. Björnmalm, A. K. Wise, C. Cortez-Jugo, E. Revalor, Y. Ju, O. M. Feeney, R. T. Richardson, E. Hanssen, R. K. Shepherd, C. J. H. Porter, and F. Caruso. 2018. Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery. ACS Applied Materials & Interfaces. 10(37): 31019-31031. doi: 1021/acsami.8b10415. Full Text Palmer, J. C., M. S. Lord, J. L. Pinyon, A. K. Wise, N. H. Lovell, P. M. Carter, Y. L. Enke, G. D. Housley, and R. A. Green. 2018. Comparing perilymph proteomes across species. Laryngoscope. 128(1): E47-e52. doi: 10.1002/lary.26885. Full Text See more publications by Andrew Wise in PubMed and Google Scholar Further information Click here to read Andrew's story.