Nicholas joined the Bionics Institute in 2010 as part of the multi-disciplinary team developing a bionic eye. In that role, he developed neurostimulation and psychophysics equipment and performed experiments with bionic eye implantees. Following the successful completion of the first-in-human trial of a suprachoroidal retinal prosthesis, Nicholas moved to the Movement Disorders team where he now works on improving Deep Brain Stimulation therapy for Parkinson’s disease and other conditions and is also undertaking a part-time PhD in this area. Prior to joining the Bionics Institute, Nicholas spent several years developing an EEG-based depth of anaesthesia monitor.

E: [email protected]

Research projects

Adaptive Deep Brain Stimulation Device (ASTUTE system)

Improved positioning for DBS (ADEPT device)

Pre-clinical validation (ERNA signal)

Improved diagnosis of Parkinson's disease (BiRD device)

Recent publications

  1. McDermott, H. J., and N. C. Sinclair. 2020. Feedback control for deep brain stimulation for motor disorders. Healthcare Technology Letters. 7(3): 72-75. doi: 10.1049/htl.2019.0119. Full Text

  2. Thevathasan, W., N. C. Sinclair, K. J. Bulluss, and H. J. McDermott. 2020. Tailoring Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Evoked Resonant Neural Activity. Frontiers in Human Neuroscience. 14(71). doi: 3389/fnhum.2020.00071. Full Text

  3. Ramirez-Zamora, A., J. Giordano, A. Gunduz, J. Alcantara, N. J. Cagle, S. Cernera, P. Difuntorum, S. Eisinger, J. Gomez, S. Long, B. Parks, J. K. Wong, S. Chiu, B. Patel, W. M. Grill, H. C. Walker, S. J. Little, R. Gilron, G. Tinkhauser, W. Thevathasan, N. C. Sinclair, A. M. Lozano, T. Foltynie, A. Fasano, S. A. Sheth, K. Scangos, T. D. Sanger, J. Miller, A. C. Brumback, P. Rajasethupathy, C. McIntyre, L. Schlachter, N. Suthana, C. Kubu, L. R. Sankary, K. Herrera-Ferrá, S. Goetz, B. Cheeran, G. K. Steinke, C. Hess, L. Almeida, W. Deeb, K. D. Foote, and S. O. Michael. 2020. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Frontiers in Human Neuroscience. 14(54). doi: 3389/fnhum.2020.00054. Full Text

  4. Sinclair, N. C., J. B. Fallon, K. Bulluss, W. Thevathasan, and H. J. McDermott. 2019. On the neural basis of deep brain stimulation evoked resonant activity. Biomedical Physics & Engineering Express. 5: 057001. doi: https://doi.org/10.1088/2057-1976/ab366e

  5. Sinclair, N. C., H. J. McDermott, J. B. Fallon, T. Perera, P. Brown, K. J. Bulluss, and W. Thevathasan. 2019. Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity. Neurobiology of disease. 130: 104522. doi: 1016/j.nbd.2019.104522.

  6. Lee, W. L., N. C. Sinclair, M. Jones, J. L. Tan, E. L. Proud, R. Peppard, H. J. McDermott, and T. Perera. 2019. Objective evaluation of bradykinesia in Parkinson's disease using an inexpensive marker-less motion tracking system. Physiological Measurement. 40(1): 014004. doi: 1088/1361-6579/aafef2.

  7. Sinclair, N. C., H. J. McDermott, K. J. Bulluss, J. B. Fallon, T. Perera, S. S. Xu, P. Brown, and W. Thevathasan. 2018. Subthalamic nucleus deep brain stimulation evokes resonant neural activity. Annals of neurology. 83(5): 1027-1031. doi: 10.1002/ana.25234. Full Text

  8. Shivdasani, M. N., N. C. Sinclair, L. N. Gillespie, M. A. Petoe, S. A. Titchener, J. B. Fallon, T. Perera, D. Pardinas-Diaz, N. M. Barnes, and P. J. Blamey. 2017. Identification of Characters and Localization of Images Using Direct Multiple-Electrode Stimulation With a Suprachoroidal Retinal Prosthesis. Investigative Ophthalmology & Visual Science. 58(10): 3962-74. Full Text

  9. Petoe, M. A., C. D. McCarthy, M. N. Shivdasani, N. C. Sinclair, A. F. Scott, L. N. Ayton, N. M. Barnes, R. H. Guymer, P. J. Allen, P. J. Blamey, and Consortium Bionic Vision Australia. 2017. Determining the Contribution of Retinotopic Discrimination to Localization Performance With a Suprachoroidal Retinal Prosthesis. Investigative Ophthalmology & Visual Science. 58(7): 3231-39. Full Text

  10. Sinclair, N. C., M. N. Shivdasani, T. Perera, L. N. Gillespie, H. J. McDermott, L. N. Ayton, and P. J. Blamey. 2016. The Appearance of Phosphenes Elicited Using a Suprachoroidal Retinal Prosthesis. Investigative Ophthalmology & Visual Science. 57(11): 4948-61. Full Text