Background and overall aims:

This project broadly examines the interface between the host and implanted materials and devices. Implanted materials may be particle-based drug delivery systems and bionic devices for delivering electrical or optical stimulation to neural tissue. Implanted materials are subject to internal and external factors that can influence the desired outcomes eg infection, inflammation, tissue capsule formation. This project will examine these biological responses using in vitro and in vivo models, with guidance from in vivo data. The project is not limited to any particular system or device but can be broadly applied to any area where a material or device is implanted to modulate neural activity, such as drug delivery systems for nerve protection/regeneration or electrical/optical devices.

The outcomes of this study will improve the interface between the host and devices by developing:

  • An understanding nature of protein corona leading to fouling
  • Anti-pathogenic/anti-microbial/anti-fouling coatings for implantable devices or nanoparticles for drug delivery
  • Methods of controlling inflammation and cellular immune infiltration, thus reducing potential rejection of the implanted material

General methods to be used in the project:

  • In vitro and animal models of inflammation
  • In vivo imaging
  • Histology 
  • RNA Seq/bioinformatics

Suitable background of students:

Biological sciences, Biomedical engineering, Neuroscience, Biochemistry, Pathology

Supervisor: A/Prof Rachael Richardson

For all enquiries please email [email protected]