Clearing perimenopausal brain fog
Why is a new treatment for perimenopausal brain fog needed?
Perimenopause refers to the transitional phase before menopause, typically lasting four to ten years, and is characterised by fluctuating hormone levels. These hormonal fluctuations can cause physical, behavioural, and cognitive challenges – including hot flushes, night sweats, sleep issues, mood changes, and brain fog – all of which can significantly impact quality of life.
Brain fog is common occurring in more than 60% of those experiencing perimenopause2 and can have considerable impacts on day-to-day functioning. Brain fog includes symptoms such as memory lapses, clouded thinking, difficulty finding words and losing track of thoughts. These symptoms impact women at a time of their lives where they are balancing the demands of raising a family and caring for parents, and symptoms can also impact career positions.
Despite the number of women impacted by of perimenopausal brain fog there has been a striking lack of research, and there are no treatments specifically targeted to these symptoms.
Research at the Bionics Institute
Led by Professor Kate Hoy, Head of the Bionics Institute Cognitive Therapeutics Research Program, the Bionics Institute will be investigating the use of Transcranial Random Noise Stimulation (tRNS) as a treatment for brain fog.
Previous studies have shown that tRNS can enhance attention, learning and memory, and that it enhances brain activity in ways that could mimic the positive effects of oestrogen on the brain. tRNS is a drug free, non-invasive form of brain stimulation, that can be self-administered at home following training. A portable stimulation unit is taken home, and stimulation is self-administered daily by applying stimulation to their scalp via two pads that are secured in place using a fitted cap.
Next steps for Bionics Institute researchers
Professor Kate Hoy plans to run a pilot trial in 30 women to investigate tRNS as a treatment for perimenopausal brain fog and, if successful, launch a larger multi-site trial with up to 100 women.
The research team
Bionics Institute researchers:
BI researchers:
Clinical collaborators:
A/Prof Caroline Gurvich
Medical Disclaimer
This article contains general information relating to a medical condition. Such information is provided for informational purposes only and does not replace medical advice given by your healthcare professional.
References
1. Australian Institute of Superannuation Media release 2023.
2. Woods et al., Menopause 2000; 7; 257-265.
